Enfamil Nutramigen Vs Gerber Soothe (A Complete Buying Guide 2023)

If you want to know which baby formula between Enfamil Nutramigen Vs Gerber Soothe is best for your baby, check out the differences and similarities between both formulas and how they can each serve your baby.

Both infant formulas are specifically made to address milk or protein allergy issues. They are excellent and highly sought after.

Enfamil Nutramigen contains MFGM and Lactoferrin components that support digestive and respiratory health and cognitive development. It also features Enflora LGG, which helps build a child’s tolerance toward cow’s milk, making it a great choice.

However, both formulas are all great choices and can serve as great alternatives to breast milk.

This article thoroughly summarizes both formulas, their features, pros and cons, their similarities, and their differences.

Table of Contents

Enfamil Nutramigen Vs Gerber Soothe – Features, Pros & Cons

Enfamil Nutramigen

Enfamil Nutramigen is a hypoallergenic formula designed to provide the nutrition your growing baby needs for optimal growth and development while helping to relieve colic from cow’s milk allergy. 

Nutramigen is designed to substitute milk-based formulas and help your child develop tolerance toward cow’s milk, thanks to the featured Enflora LGG. 

It is also enriched with complete nutrition, including DHA and Choline. 

Key Features:

  • It is designed to help your baby tolerate cow’s milk. Nutramigen is made with the probiotic LGG and has been proven to help develop oral tolerance to cow’s milk.
  • It is hypoallergenic. It is made with extensively hydrolyzed proteins that are less likely to trigger an allergic response.
  • It contains essential brain-nourishing nutrients, such as choline and DHA.
  • As experts recommend, the powdered form includes the probiotic LGG to help support digestive health.


  • It has been scientifically proven to reduce colic due to cow’s milk allergy within 48 hrs.
  • It is gentle on the baby’s sensitive stomach.
  • In addition, it provides the nutrition they need for healthy development while helping reduce future allergy challenges.
  • It doesn’t contain artificial growth hormones.
  • It is lactose-free
  • It contains Has DHA and ARA, nutrients in breast milk that aids in supporting a baby’s brain and eye development.
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  • There is the presence of palm olein and other vegetable oils that can interfere with nutrient absorption.
  • It is more expensive than Gerber Good Start. It costs about $73 on Amazon.

Nutritional Information Table

Nutrients per 100 Calories (5 fl oz)

Linoleic acid780mg


Calcium94 mg


Vitamin A300 IU
Vitamin D60 IU
Vitamin E2 IU
Vitamin K9mcg
Vitamin B660mcg
Vitamin 120.3mcg
Folic acid16mcg
Pantothenic acid500mcg
Vitamin C12mg

Preparation and Use

  • Wash hands thoroughly with mild soap & water before preparing the formula.
  • Pour the desired amount of water into the feeding bottle. Then add powder.
  • Put the cap on the bottle and shake. Feed or store immediately in the refrigerator.

Read: Enfamil Nutramigen Vs Enfamil Sensitive (2022 Review)

Gerber Soothe

Gerber Good Start SoothePro formula is the first and only formula with 2′-FL HMO and Probiotics (L.reuteri), designed to ease feeding issues – Colic, Crying, Fussiness, Gas, Mild Spit-Up, and uncomfortable poops.

It features a special ingredient called Comfort Proteins, explicitly designed for children who may develop milk allergies or sensitive stomachs.

These Comfort Proteins are small molecules that can be digested and absorbed more quickly than regular proteins. 

However, they are still proteins, not amino acids (amino acid-based formulas are even gentler; amino acids make up a protein molecule). 

Gerber Good Start SoothePro formula is also enriched with various nutrients, including Iron and DHA, as well as prebiotics and antioxidants similar to breastmilk.

Key Features

  • It features 2’-FL HMO (human milk oligosaccharide)
  • In addition to providing full nutrition, it also contains Comfort Proteins for gentleness and gentleness.
  • It features small proteins for baby tummies, which makes it easy to digest 
  • The formula tastes closest to breastmilk and is the only powder infant formula with a blend of DHA, prebiotics & probiotics, which is present in breastmilk. 
  • Non-GMO. The formula is not made with genetically engineered ingredients – G2


  • It contains 2’-FL HMO, which is a prebiotic, just like one found at significant breast milk levels.
  • It contains comforting probiotics, L. reuteri, which have been clinically proven to reduce crying time by 50%
  • It helps ease fussiness and gas.
  • It contains DHA to help support brain and eye development
  • It is more affordable than Enfamil Nutramigen. It costs about $36 on Amazon.
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  • It tends to clump during preparation
  • It sometimes has a fishy odor
  • Packaging quality issues when delivered by mail.

Nutritional Information Table

Nutrients per 100 Calories (5 fl oz)

Linoleic acid900mg


Calcium72 mg
Phosphorus40 mg
Magnesium7 mg
Iron1.5 mg
Zinc0.8 mg
Manganese15 mcg
Copper80 mcg
Iodine12 mcg
Selenium3 mcg
Sodium27 mg
Potassium108 mg
Chloride65 mcg


Vitamin A300 IU
Vitamin D60 IU
Vitamin E2 IU
Vitamin K8 mcg
Thiamin100 mcg
Riboflavin140 mcg
Vitamin B675 mcg
Vitamin 120.33 mcg
Niacin1050 mcg
Folic acid15 mcg
Pantothenic acid450 mcg
Biotin4.4 mcg
Vitamin C10 mg
Choline24 mg
Inositol6 mg

Preparation and Use

  •  For your utensils, tap or bottled water; always sterilize or boil them. 
  • Boil the water for 1 minute and cool to room temperature before preparing the formula. Always keep your hands and utensils clean before preparing the formula.


Consult your pediatrician about the appropriate formula for your baby. Infant formula containing powders is not sterile. It should not be given to premature babies or babies with immune conditions unless the doctor instructs them.

Read: Enfamil vs Similac vs Gerber (A Complete Buying Guide)

Enfamil Nutramigen Vs Gerber Soothe – Similarities & Differences


  • Enfamil and Gerber formula work to reduce the incidence of future allergies. 
  • They both contain brain-building Omega 3 DHA.
  • They are both lactose-free formulas.
  • They contain colic-fighting probiotics.

Pro Tip:

Only through your baby’s doctor will you be able to determine if your baby has colic. In addition to cow’s milk protein allergy, babies with asthma or eczema may also suffer other allergies. 


  • Gerber contains 2′-FL HMO (human milk oligosaccharide), a prebiotic found in breast milk, while Enfamil does not.
  • Enfamil contains MFGM components that are present in breast milk. Gerber does not.
  • Compared to Gerber Good Start, Nutramigen is gentler.
  • Gerber includes comfort proteins that are easy to digest for tiny baby tummies.
  • Enfamil is clinically shown to reduce colic due to cow’s milk allergy within 48 hours.
  • There is a huge price difference between the two, with Gerber being far more affordable.

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Enfamil Nutramigen Vs Gerber Soothe – Final Verdict

Looking at the features, pros, and cons of both Enfamil Nutramigen Vs Gerber Soothe formulas, you’ll have a clearer picture of how similar or different they are and how they can each serve you differently.

Gerber Good Start is more affordable than Nutramigen, so people tend to try it before Nutramigen. For most people, it is effective, but if your child shows no improvement, then you should use Nutramigen. 

I would choose Enfamil Nutramigen for two reasons. These formulas contain MFGM and Lactoferrin components that support digestive and respiratory health and cognitive development. It also features Enflora LGG, which helps build a child’s tolerance toward cow’s milk.