Enfamil Vs Similac Vs Kirkland (2023 Product Review)

Have you ever considered the impact of your baby’s diet on their overall well-being? It’s commonly believed that a well-fed baby is usually content and healthy.

As a parent, choosing what to feed your little one is a personal decision that requires careful consideration.

Exploring your baby formula options isn’t a bad idea, and asking questions like Enfamil vs Similac vs Kirkland will help you explore your options.

The truth is that all the formula is tightly regulated and reviewed by the FDA and must contain certain ingredients before approval; thus, their differences are not weighty.

One key difference between Enfamil vs Similac vs Kirkland is that Enfamil utilizes MFGM. This crucial fatty substance plays a significant role in promoting the development of a baby’s brain.

On the other hand, Similac and Kirkland use 2′-FL—Human Milk Oligosaccharide, a prebiotic that boosts the immune system.

We’ve compiled all the essential details you need to make an educated choice on these formulas, such as their nutritional contents, features, pros, cons, similarities, and differences.

What You Should Consider Before Buying Infant Formula

It is crucial to remember that these three infant formulas are all safe for consumption but offer different advantages.

When comparing Enfamil vs Similac vs Kirkland, it’s essential to consider several factors before deciding.

Before diving into the brands’ Pros, Cons, and key differences, let’s briefly review these considerations.

Main Ingredient or Base

Infant formulas usually have a main ingredient, most of which are cow’s milk-based. The specifics may vary depending on the brand and product line you choose.

A few main infant ingredients are:

  • Cows milk
  • Hydrolyzed proteins, typically derived from milk, are partially broken down for easier digestion. An example of this is the Gentlease line.)
  • Soy
  • Corn Syrup

It is important to monitor the formula your baby consumes closely, especially if they have allergies.

It could clearly indicate a dairy-based formula allergy if you notice green, foamy feces. You must seek advice from your pediatrician immediately and contemplate switching to a different formula.

Organic vs. Non-Organic

For an infant formula to be certified organic, it must meet the standards set by the FDA and the USDA. You can limit your baby’s exposure to harmful chemicals by choosing organic formulas.


Human milk oligosaccharides prebiotics found in breast milk are vital for a baby’s immune system. These prebiotics nourish the beneficial bacteria that eliminate harmful bacteria.

Scientists have recently found a way to artificially produce this prebiotic and incorporate it into infant formula (to clarify, this is a simplified explanation of a complex topic).

The objective is to provide formula-fed infants with similar immunity-boosting benefits as breastfed infants.


Switching formula can be hard on a baby’s stomach, so choosing a readily available formula or buying your preferred formula in bulk is important.

Enfamil can be found at all major retailers, while Kirkland can be purchased in bulk, but availability may depend on your local Costco or shipping options.

Enfamil Vs Similac Vs Kirkland – Features, Pros & Cons

Enfamil Baby Formula

Enfamil is widely recognized as the top baby formula brand in hospital newborns’ nurseries. It’s important to note that it may be slightly pricier than other formula brands.

See also  Enfamil Vs Similac Vs Nan Pro (A Complete Buying Guide)

This baby formula is designed to meet your baby’s nutritional needs, especially during their first year.

You’ll find all kinds of brands for different infant and toddler ages in the Enfamil brand, and they include:

  • Newborn stage: 0-3 months
  • Infant stage: 0-12 months
  • Toddler stage 2 and 3: Enfagrow 9 months-3 years.

Nutritional Information

Normal Dilution; per 100 Calories (5 fl oz)

Protein2 g
Fat5.3 g
Linoleic acid800mg


300 IU  
D60 IU
Thiamin (B1)80 mcg
K  9 mcg  
Riboflavin (B2)140 mcg
B6  60 mcg
B12 0.3 mcg  
Niacin1000 mcg  
Folic acid (FOLACIN)  16 mcg
Pantothenic acid  500 mcg  
Biotin3 mcg
C (Ascorbic acid)12 mg
Cholin24 mg
Inositol6 mg


Calcium78 mg
Phosphorus43 mg
Magnesium8 mg
Iron1.8 mg
Zinc1 mg
Manganese15 mcg
Copper75 mcg
Iodine15 mcg
Selenium2.8 mcg
Sodium27 mg
Potassium108 mg


  • It contains choline
  • It contains Omega-3-DHA
  • It contains a blend of two prebiotics.
  • Contains MFGM (Milk fat globule membrane) and Lactoferrin


  • It is an excellent source of vitamins
  • A premium source of minerals for your baby
  • It contains the essential nutrients that promote growth in newborns.
  • It has ingredients that are needed for brain development.
  • It also nourishes the body


  • The product is expensive
  • Has GMO versions
  • Packaging quality issues when delivered by mail.

Similac Formula

Similac The company Similac specializes in producing various types of baby and infant formulas that cater to the unique nutritional needs of different children.

These formulas are scientifically formulated to aid your growing child’s overall physical and mental development.

Nutritional Information

  Total dietary fiber (g) 
Energy (Cal)68
Protein (g)1.3
Fat (g)3.53
      Linoleic acid (g)0.52
      Linolenic acid (g)  0.05
     Docosahexaenoic acid       (DHA) (g)  –
     Arachidonic acid (ARA) (g)  –
Carbohydrate (g)7.6
  Total dietary fibre (g)  –
    Galactooligosaccharides (GOS) (g)  –

Vitamins and Minerals

Vitamin A (IU)189
Vitamin D3 (IU)31
Vitamin E (IU) 2.5  
Vitamin K1 (mg)  0.006
Vitamin C (mg)10
Thiamine (mg)0.07
Riboflavin (mg)0.14
Niacin (mg)0.65
Pantothenic acid (mg)0.36  
Vitamin B6 (mg)  0.04
Folic acid (mg)  0.0068  
Vitamin B12 (mg)0.00017
Biotin (mg)  0.0022
Choline (mg)9.0  
Copper (mg)0.046  
Zinc (mg)0.4  
Iron (mg)1.1  
Chloride (mg)40  
Potassium (mg)75  
Choline (mg)  9.0  
Inositol (mg)3.6
Sodium (mg)16  
Magnesium (mg)4.6  
Phosphorus (mg)26  
Calcium (mg)47  
Iodine (mg)0.012
Selenium (mg)0.0009
Manganese (mg)  0.012
Ash (g)0.4  
Carnitine (mg) 1.0
Tryptophan (mg )21.3  
Nucleotides (mg)  7.2

NB: Refer to the label for the most accurate information about the Similac product


  • It contains 2’-FL HMO
  • It contains DHA
  • It contains Lutein
  • It contains key body Vitamins – E, D &A


  • Improved Eye Q plus nutrition
  • Laden with natural vitamin E
  • It contains Vitamin E, which aids in supporting developing cells
  • It contains Vitamin D, which aids in maintaining strong bones and healthy muscles.
  • It contains Vitamin A, which aids in supporting vision, growth, cell division, and the immune system.
  • Contains DHA that supports brain and eye development
See also  Enfamil Gentlease Vs Similac (A Complete Buying Guide 2023)

Kirkland Formula

The Kirkland formula brand is also popularly known as the Costco warehouse. Abbot manufactures it, the same company that produces Similac.

Its manufacturing was done with mimicking nutrients like monoglycerides found in breast milk.

It offers complete milk-based nutrition for your baby’s first-year development, laden with the appropriate nutritional value for infants.

It lacks artificial growth hormones, gluten, or genetically engineered ingredients but contains DHA essential to help your baby’s developing eyes.

Nutritional Information

Nutrients per 100 calories

Protein2.1 g
Fat5.6 g
Carbohydrate10.6 g
Water133 g
Linoleic acid900 mg


A300 IU
D75 IU
E1.5 IU
K8 mcg
Thiamin100 mcg
Riboflavin150 mcg
Vitamin B660 mcg
Vitamin B12 0.25 mcg
Niacin1050 mcg
Folic acid15 mcg
Pantothenic acid450 mcg
Vitamin c9 mg
Inositol4.7 mg
Choline16 mg
Biotin4.4 mcg


Calcium78 mg
Phosphorus42 mg
Magnesium6 mg
Iron1.8 mg
Zinc0.75 mcg
Manganese5 mcg
Copper90 mcg
Iodine 6 mcg
Selenium2 mcg
Sodium24 mg
Potassium105 mg
Chloride65 mg


  • It lacks Palm Olein Oil to promote calcium absorption for strong bones.
  • It has a protein ratio of 52:48 whey-to-casein
  • It contains DHA (docosahexaenoic acid), which supports babies’ developing brains.
  • It also contains Lutein.
  • It contains a nutrient density of 20 kcal/oz
  • It contains 2′-FL HMO
  • It contains LNnT, another HMO naturally occurring in breast milk.
  • It is non-GMO.
  • It is also gluten-free.


  • The Kirkland formula is cost-effective and can be easily gotten at any Costco local warehouse.
  • Kirkland baby formula contains nutrients that mimic the ones found in breast milk that aid eye and brain development.
  • Kirkland baby formula is 100% non-GMO
  • The Kirkland baby formula is gentle on your baby’s tummy to aid in easy digestion..
  •  It contains vitamin D for your baby’s growth and promotes strong bones.
  • It comes in a powdered form and is easy to prepare, as it brings out all the nutritional values of the formula.


  • Mixing Kirkland formula tends to get foamier than other brands, and some babies might get gassy from this.
  • Its odor may not go down well with some babies.
  • It can cause constipation in some babies.

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Enfamil vs Similac vs Kirkland – Similarities and Differences


There are some similarities between Enfamil, Similac, and Kirkland, and they include the following.

  • They have a wide range of baby formula milk products
  • These brands have a non-GMO version of their sensitive formulas
  • FDA has declared them safe for consumption by babies
  • They contain essential ingredients needed for the holistic development of your baby.
  • They all have DHA as a manufacturing ingredient


  • In terms of price, Kirkland is perfect for parents on a budget. This is not so for Enfamil since their prices are quite high. Similac, on the other, is fair in price but not as cheap as Kirkland.
  • Enfamil utilizes MFGM, a crucial fatty substance that plays a significant role in promoting the development of a baby’s brain. On the other hand, Similac and Kirkland employ 2′-F.L. Human Milk Oligosaccharide, a prebiotic that boosts the immune system.
  • Enfamil is made from more natural ingredients than Similac and Kirkland
  • The production of Enfamil utilizes the use of lesser sugars than Similac and Kirkland
  • Choline, pantothenic acid, folic acid, and inositol are higher in Enfamil.
  • Similac is a better source of copper.
  • Similac and Kirkland are far enriched in thiamin, vitamin D, riboflavin, niacin, and biotin than in Enfamil.
  • Similac and  Kirkland contain lutein which Is lacking in Enfamil

Enfamil vs Similac vs Kirkland at a glance

All three brands have the approval of the FDA and contain the essential ingredients needed for the successful grooming of your little cutie via nutritional requirements.

Enfamil has lesser sugar, and it becomes ideal for you if you want a formula with lesser sugar for your baby.

If you prefer products with lutein and lack palm olein oil, often associated with infantile constipation, then you should go for Similac or Kirkland products.

Enfamil products are usually the costliest among the three brands of baby formula. If you’re on a budget, I’d recommend you go for Kirkland baby formula.

If you still need clarification about your choice of formula, seek the counsel of your pediatricians so that you can go for the ideal formula for your baby.

Final Thought

Presenting a comparison of the top brands of baby formula can indeed be helpful to you. And I am confident it has more than adequately answered your question regarding Enfamil vs Similac vs Kirkland.

When choosing between Enfamil, Similac, or Kirkland products, it’s important to remember that what works best for your baby matters most.

Every baby is different, so it’s recommended that you give your baby what they seem to prefer. Consulting with your pediatrician is always a good idea if you have any concerns.